Analysis of genetic basis for diversity in non-alcoholic fatty liver diseases in young adults

2016 Fiscal Year Final Research Report

• Project/Area Number: 26350891
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Applied health science
• Research Institution: Okayama University
• Principal Investigator: KOGA Hikari 岡山大学, 保健管理センター, 客員研究員 (90596131)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 脂肪性肝疾患 / 若年成人 / 遺伝的素因 / 遺伝子多型 / 血中脂質 / 白血球分画

Outline of Final Research Achievements

The genetic basis for diversity in non-alcoholic fatty liver diseases (NAFLD) in young adults was investigated by analyzing the single nucleotide polymorphisms (SNPs). Of the SNPs of the genes that have reported to be associated with the development of NAFLD, TM6SF2 SNP but not PNPLA3 SNP was significantly associated with NAFLD. Furthermore, the TM6SF2 SNP was associated with prognosis of NAFLD and low-density lipoprotein cholesterol levels in plasma. On the other hand, the PNPLA3 SNP was associated with leukocyte fraction, suggesting its association with pathogenesis of non-alcoholic steatohepatitis (NASH).

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