2016 Fiscal Year Final Research Report
Novel mechanisms for the biosynthesis of the lipid mediator regulating appetite and obesity
| Project/Area Number |
26350894
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Applied health science
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| Research Institution | Kagawa University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
UEDA Natsuo 香川大学, 医学部, 教授 (20193807)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 脂質メディエーター / リン脂質 / カルシウム / 酵素 / リゾホスファチジン酸 / ホスホリパーゼ / 肥満 / N-アシルエタノールアミン |
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| Outline of Final Research Achievements |
Fatty acyl amides (N-acylethanolamines) are endogenous lipids showing a variety of biological actions including appetite suppression and lipolysis, and are considered to negatively regulate obesity. In the present study, we found that two members of the glycerophosphodiesterase (GDE) family, GDE4 and GDE7, function as novel lysophospholipase D-type enzymes hydrolyzing precursor lysophospholipids to form fatty acyl amides. This results suggested new targets for novel anti-obesity drugs.
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| Free Research Field |
脂質生物学
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