Setting new standards for lymphocyte subsets in the elderly

2017 Fiscal Year Final Research Report

• Project/Area Number: 26350903
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Applied health science
• Research Institution: Gunma Paz University
• Principal Investigator: Fujimoto Yuka 群馬パース大学, 保健科学部, 助教 (60713336)
• Co-Investigator(Kenkyū-buntansha): 小河原 はつ江 群馬パース大学, 保健科学部, 教授 (60134293) ; 浅見 知市郎 群馬パース大学, 保健科学部, 教授 (60320652)
• Research Collaborator: Shiratsuchi Yoshiko 群馬パース大学, 保健科学部, 講師 ; Kotajima Nobuo 群馬パース大学, 保健科学部, 准教授
• Project Period (FY): 2014-04-01 – 2018-03-31
• Keywords: 加齢 / 生活習慣 / CD4/CD8 / Th1/Th2 / 制御性T細胞 / 免疫能

Outline of Final Research Achievements

We conducted a survey on lifestyle and CD4+ T counts in healthy volunteers aged 20-99 years. We then evaluated CD4+ T cell counts to determine the correlation with age and elements of lifestyle. With these data, we determined a standard value range for CD4+ T cell counts in the elderly. We observed that the ratio of CD8+ T cells to regulatory T cells (Treg) was significantly higher in the elderly than in adolescents and those in the middle-age group. We used these data to set a standard value for the ratio of CD8+ T cells to Treg cells in the elderly. We also examined the relationship between CD4+ T cell counts and the results of the Development of Health and Life Habit Inventory.2 (DIHAL.2) survey. The results suggested that the number of Th2 cells is primarily influenced by diet, and the ratio of CD8+ T cells to Treg cells is most influenced by the regularity of sleep pattern.

Free Research Field

血液学、免疫学