Personalized prevention for lifestyle-related diseases in control of reactive oxygen species

2018 Fiscal Year Final Research Report

• Project/Area Number: 26350908
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Applied health science
• Research Institution: Showa University
• Principal Investigator: KOKAZE Akatsuki 昭和大学, 医学部, 教授 (70271583)
• Co-Investigator(Kenkyū-buntansha): 木庭 新治 昭和大学, 医学部, 教授 (20276546)
• Project Period (FY): 2014-04-01 – 2019-03-31
• Keywords: ミトコンドリアDNA / 遺伝子多型 / コーヒー / 肝障害 / 赤血球パラメーター / 血清クロール / 眼圧

Outline of Final Research Achievements

Longevity-associated mitochondrial DNA 5178 C/A polymorphism modifies the effects of cigarette smoking on the risk of liver injury and those of coffee consumption on erythrocytic parameters, risk of liver injury, serum chloride level and intraocular pressure. These findings will contribute the establishment of personalized behavior modification program for the prevention of lifestyle-related diseases.

Free Research Field

衛生学公衆衛生学

Academic Significance and Societal Importance of the Research Achievements

Mt5178C/A多型と喫煙習慣との肝障害リスクに対する交互作用、Mt5178C/A多型とコーヒー飲用との赤血球パラメーター、肝障害リスク、血清クロール値、眼圧に対する交互作用は、生活習慣病のためのテーラーメイド予防法の開発に役立つと思われる。