Age-dependent changes of risk factors determining the survival of patients

2016 Fiscal Year Final Research Report

• Project/Area Number: 26350915
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Applied health science
• Research Institution: Tokyo University of Technology
• Principal Investigator: YAMAMOTO Yorihiro 東京工科大学, 応用生物学部, 教授 (60134475)
• Co-Investigator(Renkei-kenkyūsha): KINOSHITA Kosaku 日本大学, 医学部附属板橋病院, 教授 (90260968) ; SAKURAI Atsusi 日本大学病院, 准教授 (40339320)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 酸化ストレス / コエンザイムQ10 / 遊離脂肪酸 / 尿酸 / プロサポシン / 心肺停止救急患者 / ALS / 敗血症

Outline of Final Research Achievements

In order to find out risk factors determining the survival of patients, we measured plasma levels of oxidized form of coenzyme Q10 (%CoQ10) and free fatty acids and their compositions in patients with ALS and PCAS. These levels were significantly different from those in healthy controls, indicating a significant increase of oxidative stress in these patients. Time course changes indicated that %CoQ10 decreased in patients who discharged in a week but remained unchanged in patients who died. Plasma level of prosaposin, a coenzyme Q10 binding and transfer protein, increased significantly, suggesting that coenzyme Q10 is necessary in a critical condition. It is interesting plasma levels of prosaposin in normal people increase with age.

Free Research Field

医化学