2016 Fiscal Year Final Research Report
Does melatonin control advanced glycation end products (AGEs) and their receptor (RAGE) ?
| Project/Area Number |
26350917
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Applied health science
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| Research Institution | Doshisha University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | メラトニン / SaMT / 糖化ストレス / 蛋白糖化最終生成物(AGEs) / 睡眠 / 糖脂質代謝 / 糖尿病 |
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| Outline of Final Research Achievements |
Glycative stress control includes 1. Prevention of advanced glycation end product (AGE) formation, 2. AGE breaking and 3. AGEs/RAGE (Receptor for AGE) signal control. In our experiment, melatonin did not showed prevention of AGE formation nor inhibition of AGEs/RAGE signal, but showed the enhancing action of AGE breaking. Furthermore, to evaluate melatonin secretion, we measured urine 6-OH-melatonin sulfate (SaMT), a melatonin metabolite, and found that human urine SaMT correlated to growth hormone/IGF-I secretion but were not detected in mouse urine. Melatonin seems to play a role in the mechanism that the high quality sleep reduces the glycative stress. Urine SaMT may contribute to evaluate the sleep quality.
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| Free Research Field |
抗加齢医学
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