2016 Fiscal Year Final Research Report
Developmental changes of myocardial repolarization characteristics in neonate
| Project/Area Number |
26350944
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Childhood science (childhood environment science)
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| Research Institution | Fujita Health University |
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Principal Investigator |
Hata Tadayoshi 藤田保健衛生大学, 保健学研究科, 教授 (70267954)
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| Research Collaborator |
UCHIDA Hidetoshi
NAGATANI Arisa
TAKEUCHI Yuka
MIZUTANI Yuri
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 心筋再分極 / 自律神経活動 / QT interval / J point to peak interval / QT variability index / JTp variavility index |
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| Outline of Final Research Achievements |
Background: The QT variability index (QTVI) provides a ratio of normalized QT variability to normalized heart rate variability, and therefore includes an assessment of autonomic nervous activity. However, measurement of QT time is particularly difficult in children, who exhibit physiologically high heart rates compared with adults. Purpose: In this study, we developed a set of standard values of J point to Tpeak interval (JTp) for infants by age, and assessed the correlation of QTVI with the JTp variability index (JTpVI).
Methods: Subjects included 623 infants and children (0 to 7 years of age) and 57 healthy university students. Subjects were divided into three groups by age. Results: JTpVI markedly decreased in infancy and slowly decreased thereafter, reaching adult values by school age. There was also a strong correlation of JTpVI with QTVI. Conclusions: JTp can be used to evaluate the variability of the repolarization time.
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| Free Research Field |
心臓電気生理学
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