Role of intestinal flora and its related metabolites in influences of high-fat diet on intestinal diseases

2016 Fiscal Year Final Research Report

• Project/Area Number: 26350960
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Biomolecular chemistry
• Research Institution: Kobe University
• Principal Investigator: NISHIUMI SHIN 神戸大学, 医学研究科, 特命准教授 (20514706)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 高脂肪食 / メタボロミクス / 代謝物 / 腸管腫瘍 / 腸炎 / 腸内細菌

Outline of Final Research Achievements

The aim of this study was to investigate whether the successive intake of high-fat diet affects the pathogenesis of intestinal tumor and inflammatory bowel disease, and to find the candidates of intestinal flora-related metabolites that contribute to the pathogenesis of intestinal tumor and inflammatory bowel disease. As a result, I could suggest the possibility that quality of the fat affects the pathogenesis more greatly than quantity of the fat. In addition, I could clarify the possibility that sarcosine, which is one of amino acids, is one of the candidates of intestinal flora-related metabolites that contribute to the pathogenesis of intestinal tumor.

Free Research Field

メタボロミクス