2016 Fiscal Year Final Research Report
Elucidation of immunomodulatory effects of probiotic bacterial components
| Project/Area Number |
26350961
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Biomolecular chemistry
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| Research Institution | Kagoshima University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Keywords | 自然免疫 / 構造解析 / 酢酸菌 / リポ多糖 / 外膜小胞 |
|---|
| Outline of Final Research Achievements |
Probiotic bacteria and their bacterial components are known to keep the host homeostasis and modulate the host immune systems by interacting with intestinal immune cells. Previously we found that a traditional Japanese vinegar kurozu contains acetic acid bacterial components including lipoproteins and lipopolysaccharide, which are considered to contribute to host immune system modulation. In this study, we elucidated chemical structure of the lipopolysaccharide and found that the lipopolysaccharide exist as nano-sized vesicles in kurozu.
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| Free Research Field |
複合新領域
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