2017 Fiscal Year Final Research Report
Elucidation of structure-function relationship of HSPB1 in anticancer drug resistance mechanism
| Project/Area Number |
26350963
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Biomolecular chemistry
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| Research Institution | Osaka Medical College |
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Principal Investigator |
SAKAI AKIKO 大阪医科大学, 医学部, 講師 (30225750)
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| Co-Investigator(Kenkyū-buntansha) |
田中 覚 大阪医科大学, 医学部, 非常勤講師 (50595741)
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Keywords | HSPB1 / 抗癌剤耐性 |
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| Outline of Final Research Achievements |
The heat-shock protein (HSP) B1 expression increased with the acquisition of 5-fluorouracil resistance. We analyzed the phosphorylation and oligomeric structure of HSPB1 in anticancer agent 5-fluorouracil and paclitaxel-resistant cells, demonstrated that the oligomeric structures and phosphorylation of HSPB1 in both resistant cells are defferent. In addition, cytokeratin subtypes and other two proteins were identified as proteins that interact with HSPB1.
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| Free Research Field |
生物学
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