Development of a high efficient screening technique of small molecules binding to a target site of protein

2016 Fiscal Year Final Research Report

• Project/Area Number: 26350976
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Chemical biology
• Research Institution: Institute of Physical and Chemical Research
• Principal Investigator: Kondoh Yasumitsu 国立研究開発法人理化学研究所, 環境資源科学研究センター, 専任研究員 (80333342)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: ケミカルアレイ / プロリンリンカー / p38MAPキナーゼ

Outline of Final Research Achievements

Small molecules are important tools to investigate biological system in chemical biology research. A strategy is important for efficient screening of small molecules specifically binding to target protein from chemical library. In this research, I have developed technology to improve detectivity of chemical array and method for efficient screening of small molecules specifically binding to a focused site of target protein using the advanced chemical array.

Free Research Field

ケミカルバイオロジー