Utilization of microenvironment of nanotubes in in-vitro evolution

2016 Fiscal Year Final Research Report

• Project/Area Number: 26350978
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Chemical biology
• Research Institution: National Institute of Advanced Industrial Science and Technology
• Principal Investigator: Kubo Tai 国立研究開発法人産業技術総合研究所, 創薬分子プロファイリング研究センター, 副研究センター長 (10178030)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 試験管内進化 / マイクロ環境 / リフォールディング / 生理活性ペプチド / 分子進化

Outline of Final Research Achievements

We have found that organic nanotubes promoted refolding and thus leading innate activity of peptides when applied to the in-vitro translation reaction of the peptides. The observation was successfully adopted to the in-vitro evolution technology to construct a random peptide library with improved content of active peptides.

Free Research Field

分子進化工学