Why malaria infections including non-human primate malaria infection occurred in specific group

2017 Fiscal Year Final Research Report

• Project/Area Number: 26360029
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Area studies
• Research Institution: Fujita Health University
• Principal Investigator: Maeno Yoshimasa 藤田保健衛生大学, 医学部, 准教授 (70131191)
• Co-Investigator(Kenkyū-buntansha): 中澤 秀介 長崎大学, 熱帯医学研究所, 助教 (20180268) ; 高木 秀和 愛知医科大学, 医学部, 講師 (90288522)
• Research Collaborator: KAWAI Satoru ; MASUDA Gaku ; SHINE Toshihiko ; Quang Nguyen Tuyen ; Culleton Richard ; Marchand Ron P. ; Huffman Michael Alan ; Chinh Vu Duc ; Hung Vu Viet
• Project Period (FY): 2014-04-01 – 2018-03-31
• Keywords: マラリア / 住民 / 媒介蚊 / サルマラリア / 疫学調査 / 分子生物学 / サルマラリア原虫 / ベトナム

Outline of Final Research Achievements

Recent molecular epidemiological studies in Vietnam have reported cases of co-infection with Plasmodium falciparum, P. vivax, P. malariae, and P. knowlesi in An. dirus. The commonly found macaques in the forest in the forested areas are suspected to be bitten by the same An. dirus population that bites humans. Our epidemiological study identified six species of malarial parasites in sporozoite-infected An. dirus using PCR, of which P. vivax was the most common, followed by P. knowlesi, P. inui, P. cynomolgi, P. coatneyi, and P. falciparum. Based on a gametocyte analysis, the same allelic gametocyte types were observed in both humans and mosquitoes at similar frequencies. These observations suggest that people who stay overnight in the forests are frequently infection with both human and non-human primate malarial parasites, leading to the emergence of novel zoonotic malaria. Moreover, it is suggested that mosquito vector populations should be controlled and monitored closely.

Free Research Field

寄生虫学