Relationship between applied behavior analysis and therapeutics in animal models of ADHD

2016 Fiscal Year Final Research Report

• Project/Area Number: 26380894
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Educational psychology
• Research Institution: Fukuoka Prefectural University
• Principal Investigator: Mugishima Go 福岡県立大学, 人間社会学部, 准教授 (40308143)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 実験系心理学 / 発達障害 / 生理心理学 / 行動分析学

Outline of Final Research Achievements

ADHD (attention deficit hyperactivity disorder) is a developmental disorder to assume cardinal symptoms including inattention, impulsivity and hyperactivity, which is assumed some neural dysfunctions related catecholamine neuron. In this study, impulsivity and inattention ware investigated in EL mouse and spontaneously hypertensive rat (SHR) as animal models of ADHD. As the results, 1) EL mouse put much higher value on immediacy than amount of reward on delay discount paradigm, suggesting high impulsivity. 2)Atomoxetine alleviated the impulsive choice in EL mouse. 3) EL mouse exhibited impaired performance on latent inhibition, suggesting inattention. 4) SHR showed insufficient mismatch negativity like response on cerebral cortex to the acoustic stimuli that elicited stream segregation, indicating pre-attentive dysfunction in segregating stream. Methylphenidate alleviated this pre-attentive dysfunction, although induced the ADHD like response of EEG on control strain (WKY) adversely.

Free Research Field

生理心理学