Development of time-limitable hydrogels controlled by peptide self-assembly

2016 Fiscal Year Final Research Report

• Project/Area Number: 26390022
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Nanomaterials chemistry
• Research Institution: Doshisha University
• Principal Investigator: Koga Tomoyuki 同志社大学, 理工学部, 教授 (10388043)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: ペプチド / 自己組織化 / ハイドロゲル / 時限性 / ナノバイオ材料

Outline of Final Research Achievements

Advances in peptide self-assembly provide strong incentives to fabricate novel nanostructured biomaterials. In this study, novel intelligent hydrogels that show gel-to-sol transition in response to time under constant physical condition were fabricated through programmed peptide self-assembly. Three-armed collagen-mimetic short peptides (CMP) were newly designed and synthesized as building units for self-assembly. A detailed characterization of the CMPs was performed in water by CD, SEM, TEM, AFM and rheological measurements. By tuning the chain length and amino acid sequence, we could successfully obtain various CMP-based hydrogels with different lifetime of gel-state.

Free Research Field

高分子化学