Simulation of pathgenesis of influenza A/H5N1 and prevention

2016 Fiscal Year Final Research Report

• Project/Area Number: 26400210
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Foundations of mathematics/Applied mathematics
• Research Institution: Josai University
• Principal Investigator: YASUDA HIDENORI 城西大学, 理学部, 教授 (30406368)
• Co-Investigator(Renkei-kenkyūsha): SUZUKI Kazuo 帝京大学, アジア国際感染症制御研究所, 教授 (20192130) ; KAWACHI Shohji 帝京大学, アジア国際感染症制御研究所, 教授 (60152972)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 数理モデル / 数値シミュレーション / 新型インフルエンザ / 白血球減少症

Outline of Final Research Achievements

In this study, we developed a numerical within-host model and performed simulations to reproduce the pathology of leukopenia peculiar to highly pathogenic avian influenza A / H 5 N1. As a mathematical model, we first developed a model by delay differential equation system. Although leukopenia could be reproduced, the system became stiff. It was difficult to combine the within-host model with a transmission model in a local community from the view point of computation time. Then, we next developed an ordinary differential equation model and identified parameters using experimental data. Furthermore, the effectiveness of neuraminidase inhibitor therapy and immunoglobulins therapy were evaluated using the ordinary differential equation model. High-speed simulation coupled with transmission model becomes possible.

Free Research Field

応用数学