Search for the liquid-ordered phase appeared in cholesterol-free lipid bilayers

2016 Fiscal Year Final Research Report

• Project/Area Number: 26400431
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Biological physics/Chemical physics/Soft matter physics
• Research Institution: Kyoto Institute of Technology
• Principal Investigator: Yao Haruhiko 京都工芸繊維大学, 材料化学系, 准教授 (60212271)
• Research Collaborator: KOMAKI Hiroyuki 京都工芸繊維大学, 材料制御化学専攻, 大学院生 ; YOSHIKAWA Yuki 京都工芸繊維大学, 材料制御化学専攻, 大学院生
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 脂質二分子膜 / 秩序液体相

Outline of Final Research Achievements

The liquid ordered(lo) phase in cholesterol-free lipid bilayers has been searched using ultra-high-sensitivity DSC developed in our laboratory. Multiple heat anomalies were found near the gel to liquid-crystalline phase transition of diundecanoyl phosphatidylcholine(DC11PC), ditridecanoyl phosphatidylcholine(DC13PC) and dimyristoyl phosphatidylgrycerol(DC14PG). The packing of hydrocarbon chains of the systems was investigated with X-ray diffraction. It was found that the lo phase existed as an intermediate phase near the gel to liquid-crystalline phase transition of DC11PC, DC13PC and DC14PG.

Free Research Field

ソフトマターの物理