Oxidative cross-coupling of enolate species

2017 Fiscal Year Final Research Report

• Project/Area Number: 26410046
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Organic chemistry
• Research Institution: Osaka University
• Principal Investigator: Amaya Toru 大阪大学, 工学研究科, 助教 (20397615)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Keywords: 酸化的クロスカップリング / ボロンエノラート / バナジウム

Outline of Final Research Achievements

Oxidative cross-coupling of enolate species is a useful reaction to synthesize unsymmetrical 1,4-dicarbonyl compounds directly from two different enolate species. However, the formation of homo-coupling product has been an issue in this reaction. In this study, we aimed to develop a method for the selective oxidative cross-coupling of enolate species. The key of our strategy is based on the control of the reactivity by the counter cation metal species of the enolate. As a result, we achieved to demonstrate that the oxidative cross-coupling proceeds selectively by combining boron enolate and silyl enolate in the presence of vanadium (V) as an oxidant.

Free Research Field

有機合成化学