Development of environmental friendly synthesis using novel bis(imidazoline)-metal catalysts

2016 Fiscal Year Final Research Report

• Project/Area Number: 26410117
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Synthetic chemistry
• Research Institution: Nagoya Institute of Technology
• Principal Investigator: NAKAMURA Shuichi 名古屋工業大学, 工学(系)研究科(研究院), 准教授 (20335087)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 不斉合成 / 環境調和型合成 / 有機合成 / エナンチオ選択的 / 生物活性物質 / 触媒

Outline of Final Research Achievements

In order to develop the catalytic enantioselective reactions and environmentally friendly reaction process, we designed novel chiral catalysts. In particular, we designed and synthesized an asymmetric bis(imidazoline) catalyst, developed various asymmetric synthesis reactions, investigated synthesis of biologically active substances, and analyzed reaction mechanism. As a result, we successfully synthesized optically active amines using the developed bisimidazoline-palladium catalyst based on the activation of nitriles which have not been achieved so far. It was also possible to establish the asymmetric synthesis technique in water, establish the recycling method of catalyst recovery, and developed environmentally conscious asymmetric synthesis technology.

Free Research Field

有機合成化学