2016 Fiscal Year Final Research Report
Development of one-pot enantioselective construction of densely functionalized bicyclic compound using organocatalyst
| Project/Area Number |
26410121
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Synthetic chemistry
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| Research Institution | Hiroshima University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 有機分子触媒 / Michael反応 / 不斉合成 / エナンチオ選択性 |
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| Outline of Final Research Achievements |
In this research, one-pot asymmetric construction of densely functionalized bicyclic compound by successive Michael reactions of cyclohexanone derivatives and acrylate derivatives bearing a leaving group was investigated. The enantioselective intramolecular Michael reaction of cyclohexanone derivatives and acrylate derivatives, which is essential for the asymmetric construction, was achieved by using quaternary ammonium salt derived from cinchona alkaloid. On the basis of the enantioselective Michael reaction, one-pot asymmetric construction of densely functionalized bicyclic compounds was also achieved.
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| Free Research Field |
有機合成化学
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