2016 Fiscal Year Final Research Report
Synthesis of Nitroaniline Derivatives by a Built-in Method of Unstable Nitromalonaldehyde
| Project/Area Number |
26410123
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Synthetic chemistry
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| Research Institution | Kochi University of Technology |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 環変換反応 / ニトロピリジン / ニトロアニリン / ビシクロ中間体 |
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| Outline of Final Research Achievements |
Three component ring transformation of dinitropyridone, ketone, and ammonium acetate proceeded to afford nitropyridines and nitroanilines. These products are not easily available by alternative methods. To the contrary, the present method requires only simple experimental manipulations. In addition, modification of the product can be easily perfomed by only changing the ketone. Hence, it is applicable to various purposes.
The synthesized products have both electron-donating and -withdrawing groups, which brings about the biased electron density. Such frameworks are often used for biologically compounds and optical materials. Hence, the present method facilitates the development of new functional materials.
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| Free Research Field |
有機合成化学
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