2016 Fiscal Year Final Research Report
Developments of the absolute asymmetric synthesis of optically active derivatives of amino acids with the dynamic preferential crystallization
| Project/Area Number |
26410124
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Synthetic chemistry
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| Research Institution | Chiba Institute of Technology |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 不斉合成 / 不斉増幅現象 / 有機結晶 / コングロメレート |
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| Outline of Final Research Achievements |
We demonstrated a new asymmetric synthesis involving a reaction of an achiral substrate in a solution followed by dynamic crystallization. The asymmetric induction and amplification has been clarified by the fact that chiral products are generated by the reaction of achiral compounds and racemization and preferential crystallization of the chiral center generated simultaneously occur in the system. Using this methodology, absolute asymmetric synthesis of amino acid derivatives and medicinal intermediates were achieved. We could disseminate innovative research results widely both in Japan and abroad.
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| Free Research Field |
有機化学
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