Synthesis of main-chain chiral polymers of organocatalyst and their application to asymmetric reaction

2016 Fiscal Year Final Research Report

• Project/Area Number: 26410133
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Polymer chemistry
• Research Institution: Toyohashi University of Technology
• Principal Investigator: Haraguchi Naoki 豊橋技術科学大学, 工学(系)研究科(研究院), 准教授 (30378260)
• Co-Investigator(Renkei-kenkyūsha): Itsuno Shinichi 豊橋技術科学大学, 大学院工学研究科, 教授 (50158755)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: キラル高分子 / 有機分子触媒 / 不斉反応 / 高分子触媒 / キラルイミダゾリジノン / シンコナアルカロイド / 溝呂木-Heck重合 / イオン結合

Outline of Final Research Achievements

We have successfully synthesized mai-chain chiral polymers containing chiral organocatalyst by the polymerization of chiral organocatalyst with selected linkers. Chiral organocatalst moiety is quantitatively and regularly introduced into the polymer main chain.
The resulting main-chain chiral polymers were used as polymer-immobilized chiral organocatalysts for various asymmetric reactions. By optimizing the reaction conditions and polymer structure, the catalytic activity of the polymeric chial organocatalyst was comparable or even higher than that of model catalyst. In addition, the polymeric catalyst could be reused several times without loss of catalytic activity.

Free Research Field

高分子合成、高分子触媒