2016 Fiscal Year Final Research Report
Identification of biological activities mediated by GPCR in dynamic equilibrium state of monomer and dimer
| Project/Area Number |
26410182
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Bio-related chemistry
|
|---|
| Research Institution | Saga University |
|---|
Principal Investigator |
KODAMA HIROAKI 佐賀大学, 工学(系)研究科(研究院), 教授 (80205418)
|
|---|
| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Keywords | シグナル伝達 / GPCR / 二量体 / ペプチド合成 / 活性酸素 |
|---|
| Outline of Final Research Achievements |
Many GTP coupled receptors exits as homodetic and heterodetic dimeric forms on the biological membrane and the functions of two protomers of dimeric GPCR have not been elucidated. To understand the functions of protomers of formyl peptide receptors, heterodetic dimeric peptides of peptides with the high selectivities for two receptor subtypes were synthesized. From the results of biological assays, dimeric peptides interact with the two protomers.
|
| Free Research Field |
化学
|
