Studies on structural biology of the enzymes involved in porphyria

2016 Fiscal Year Final Research Report

• Project/Area Number: 26410186
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Bio-related chemistry
• Research Institution: Yokohama College of Pharmacy
• Principal Investigator: OMATA Yoshiaki 横浜薬科大学, 薬学部, 教授 (20268840)
• Co-Investigator(Renkei-kenkyūsha): HIGASHIMOTO Yuichiro 久留米大学, 医学部, 教授 (40352124) ; SATO Hideaki 久留米大学, 医学部, 准教授 (60271996) ; SUGISHIMA Masakazu 久留米大学, 医学部, 准教授 (30379292)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: ポルフィリン生合成 / ポルフィリン症 / ウロポルフィリノーゲンIII合成酵素 / ヒドロキシメチルビラン合成酵素

Outline of Final Research Achievements

Heme contained in hemoglobin and others is an essential substance for most organisms. In the case of human, defect in its biosynthetic pathway enzyme causes a disease called porphyria. The patients of porphyria can not get outdoors on daytime in some cases due the increased light sensitivity that is general symptom of porphyria. In order to contribute to the drug discovery for porphyria and the treatment of patients, a detailed reaction mechanism of enzymes involved in heme biosynthesis was studied by using chemically synthesized analogs of substrate and slightly modified enzymes of function.

Free Research Field

酵素反応学