Imaging and Drug Delivery to Sentinel Lymph Node by Using All-In-One Dendrimers

2016 Fiscal Year Final Research Report

• Project/Area Number: 26410227
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Polymer/Textile materials
• Research Institution: Osaka Prefecture University
• Principal Investigator: Kojima Chie 大阪府立大学, 工学(系)研究科(研究院), 准教授 (50405346)
• Co-Investigator(Renkei-kenkyūsha): KONDO Eisaku 新潟大学, 医歯学総合研究科, 教授 (30252951)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: イメージング / デンドリマー / リンパ節 / ガン治療

Outline of Final Research Achievements

Because cancer is a leading cause of death in Japan, development of imaging technology for cancer diagnosis and drug delivery systems for cancer therapy are crucial. Dendrimers are synthetic macromolecules with highly controllable structures, which are potent multifunctional imaging agents and drug carriers. The detection of the sentinel lymph node (SLN), the first lymph node draining tumor cells, is important in cancer diagnosis and therapy. First, the optimal dendrimer structure for SLN imaging was investigated. Carboxyl-terminal dendrimers of greater than G4 were mostly located in the SLN. SLN detection was successfully performed by nuclear medicinal imaging and fluorescent imaging using these dendrimers. Finally, triply functional dendrimers with tumor targeting activities, antitumor effects and detectable probes were prepared.

Free Research Field

高分子材料、ナノメディシン