2016 Fiscal Year Final Research Report
Development of PLLA porous nanofiber scaffold for tissue regeneration by using electrospinning method
| Project/Area Number |
26420027
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Materials/Mechanics of materials
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| Research Institution | Doshisha University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 組織再生 / ファイバースキャホールド / 多孔質中空構造 / ポリ乳酸 / エレクトロスピニング / 栄養供給 |
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| Outline of Final Research Achievements |
In this study, PLLA porous hollow fiber scaffold was developed by using electrospinning to maintain nutrient supply in cultured cartilage. Porous hollow fiber scaffold was fabricated by using the co-axial spinneret. PLLA/PEO solution as the outer solution was prepared by dissolving poly-L-lactic acid (PLLA) and polyethylene oxide (PEO) in 1,3-dioxolane. 40% ethanol was used as the inner solution. According to SEM observation, the fabricated fiber had porous hollow structure. According to fluorescent observation of diffusion of fluorescent solution through the fiber, the developed PLLA porous hollow fiber scaffold had an interconnected structure to maintain supply of a culture medium in cultured cartilage.
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| Free Research Field |
工学
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