Development and verification of numerical simulation for microbubble-enhanced high-intensity focused ultrasound therapy

2016 Fiscal Year Final Research Report

• Project/Area Number: 26420125
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Fluid engineering
• Research Institution: Nihon University
• Principal Investigator: OKITA Kohei 日本大学, 生産工学部, 准教授 (20401135)
• Co-Investigator(Renkei-kenkyūsha): YOSHINAKA Kiyoshi 産業技術総合研究所, 健康工学研究部門, 研究員 (90358341) ; AZUMA Takashi 東京大学, 医学系研究科, 教授 (90421932)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: キャビテーション / マイクロバブル / 超音波 / シミュレーション / 医用工学

Outline of Final Research Achievements

The efficient tissue ablation by controlling the inertial cavitation has been desired for the reduction of treatment time in current high-intensity focused ultrasound (HIFU) therapy. In the present study, the numerical simulator treating cavitation/microbubble in the ultrasound field has been developed. The simulator takes into account the heat generation due to oscillating cavitation bubbles as well as the rectified diffusion which has important role in the initial stage of cavitation bubble growth. The influences of various parameters of ultrasound on the inception of cavitation was investigated. And, the enhancement of localised heating in the cavitation-enhanced HIFU therapy was demonstrated by the present numerical simulation. Furthermore, validation data for the numerical simulation was obtained experimentally and was compared with the calculation result.

Free Research Field

流体工学