Development of new treatments of peritoneal disorders using multi-layered, in situ cross-likable hydrogels

2016 Fiscal Year Final Research Report

• Project/Area Number: 26420792
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Biofunction/Bioprocess
• Research Institution: The University of Tokyo
• Principal Investigator: Ito Taichi 東京大学, 大学院医学系研究科(医学部), 准教授 (50447421)
• Co-Investigator(Renkei-kenkyūsha): KITAYAMA Joji 自治医科大学, 附属病院, 教授 (20251308) ; KOKUDO Norihiro 国立国際医療センター, 理事長 (00205361)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: ハイドロゲル / スプレー / バイオマテリアル / 腹膜癒着 / 癒着防止 / 中皮細胞

Outline of Final Research Achievements

In situ crosslinkable hydrogels are potential to prevent peritoneal adhesions in laparoscopy. However, it is expected that resection side of the gels and peritoneum side of the gels have wound healing function and barrier function, respectively. This is usually a trade-off relationship in medical engineering. We hypothesized that several materials should be suitably assembled in order to break this trade-off based on chemical engineering. In fact, we formed double-layered hydrogels in situ on trauma by a spray device, and the double-layered gel showed better performance to prevent adhesions than single-layered hydrogels.

Free Research Field

医用化学工学