2016 Fiscal Year Final Research Report
Functional roles of BRAG1 at the excitatory postsynapse
| Project/Area Number |
26430040
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Nerve anatomy/Neuropathology
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| Research Institution | Kitasato University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | Arf6 / BRAG1 / シナプス |
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| Outline of Final Research Achievements |
In the present study, I focused on BRAG1, one of the excitatory postsynaptic molecules, which causes nonsyndromic mental retardation in human. To reveal the functional mechanisms of BRAG1 at postsynapse, BRAG1 knockout mice were generated. Using BRAG1 knockout mice, many neuronal and glial marker molecules were screened by immunoblot and immunohistochemical assays. Consequently, loss of BRAG1 was accompanied by upregulation of some glutamate receptor subunits in the hippocampus, and impairment of the passive avoidance task. These results suggest that BRAG1 plays important roles in the regulation of the glutamate receptor localization at excitatory post synapse and hippocampus-dependent memory.
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| Free Research Field |
神経科学
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