2016 Fiscal Year Final Research Report
Elucidation of roles of CRMP in neural circuit formation and regeneration and application for the treatment of spinal cord injury
| Project/Area Number |
26430043
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Nerve anatomy/Neuropathology
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| Research Institution | Waseda University |
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Principal Investigator |
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| Research Collaborator |
NAGAI Jun
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 大脳皮質形成 / 樹状突起形成 / スパイン形成 / 神経再生 / 脊髄損傷 |
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| Outline of Final Research Achievements |
In present study, we analyzed the role of CRMP family proteins in brain development and neural regeneration by using mutant mice of CRMP genes. We reported orientation abnormality of basal dendrites of layer V neurons in cerebral cortex of CRMP4 KO mice and this phenotype became worse in CRMP 1/4 double KO mice (Takaya et al., 2017). We also reported the involvement of CRMP2 phosphorylation in dendritic spine formation (Jin et al., 2016). In neural regeneration, we found that suppression of CRMP2 phosphorylation promoted functional recovery of motor and sensory system after spinal cord injury (Nagai et al., 2016). We further showed that LKE, which modified the function of CRMP2, also promoted recovery of motor function after spinal cord injury (Kotaka et al., 2017). These results indicate the importance of CRMP family proteins in brain development and their involvements in neural regeneration.
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| Free Research Field |
神経科学
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