Functional neuroanatomical study on cortical adult neurogenesis.

2016 Fiscal Year Final Research Report

• Project/Area Number: 26430044
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Nerve anatomy/Neuropathology
• Research Institution: Mukogawa Women's University (2015-2016); Fujita Health University (2014)
• Principal Investigator: Ohira Koji 武庫川女子大学, 生活環境学部, 准教授 (80402832)
• Co-Investigator(Renkei-kenkyūsha): Miyakawa Tsuyoshi 藤田保健衛生大学, 総合医科学研究所, 教授 (10301780)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 成体神経新生 / 抑制性神経細胞 / 大脳皮質 / 神経保護 / 再生医療

Outline of Final Research Achievements

We have found the neural progenitor cells, L1-INP cells, in the adult cortex. In this study, we further analyzed L1-INP cells, using neuroanatomical methods. First, we determined the protocols for 3D-SEM analysis of L1-INP cells. Second, we found that the density of L1-INP cells was kept from 5- to 12-month-old, dramatically decreased at 17-month-old, and thereafter maintained the same level until 24-month-old. Additionally, the degrees of decreased densities of NPCs in the cingulate and insular cortices were significantly smaller than those in the primary motor and somatosensory cortices. Finally, we made anti-TrkB-T1, which is
useful for studying the mechanism underlying adult neurogenesis of L1-INP cells. We obtained antiserum for TrkB-T1 in one out of three guinia pigs.

Free Research Field

神経科学