Study of the function of FILIP on the neuron morphology

2016 Fiscal Year Final Research Report

• Project/Area Number: 26430045
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Nerve anatomy/Neuropathology
• Research Institution: Hyogo Medical University
• Principal Investigator: Yagi Hideshi 兵庫医科大学, 医学部, 教授 (10303372)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: ミオシン / アクチン / 神経細胞

Outline of Final Research Achievements

We investigated the mechanism of morphological control of neurons that have an essential role in the function of the nervous system. FILIP which expression is observed in the central nervous system and spinal ganglia controls neuronal cell morphology through the control of intracellular distribution of non-muscle myosin IIB. In this study, we revealed that the function of Hsc70 was indispensable for the control mechanism of non-muscle myosin IIB via FILIP. We also revealed that the function of Hsc70 was involved in the function of FILIP that controls neuronal morphology.

Free Research Field

神経科学