Roles of stress granules in the disease process of multiple system atrophy

2016 Fiscal Year Final Research Report

• Project/Area Number: 26430049
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Nerve anatomy/Neuropathology
• Research Institution: Hirosaki University
• Principal Investigator: MORI FUMIAKI 弘前大学, 医学研究科, 准教授 (60200383)
• Co-Investigator(Renkei-kenkyūsha): MIKI YASUO 弘前大学, 大学院医学研究科, 助教 (30709142)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 多系統萎縮症 / MSA / αシヌクレイノパチー / 封入体 / ストレス顆粒 / RNA / RNA結合タンパク質 / HuR

Outline of Final Research Achievements

Stress granules are cytoplasmic messenger ribonucleoprotein particles that form dense aggregations in the cytosol composed of RNAs and RNA binding proteins that appear when translation is impaired under stress conditions. Stress granuless are thought to play an important role in the pathogenesis of neurodegenerative diseases by acting as seeds for pathological inclusions. To elucidate the significance of formation of stress granule and protein aggregates in the disease process of multiple system atrophy, we examined dynamic changes of stress granule-related proteins and protein degradation systems using tissue samples from multiple system atrophy patients and normal controls and cell and animal models for alpha-synucleinopathy. These results suggested that stress granules marker proteins and protein degradation systems may be therapeutic targets to prevent multiple system atrophy.

Free Research Field

神経病理学