2016 Fiscal Year Final Research Report
Globular glial tauopathy: investigation of the pathological features
| Project/Area Number |
26430052
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Nerve anatomy/Neuropathology
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| Research Institution | Niigata University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | タウオパチー / アストロサイト / globular glial tauopathy / オリゴマー / 神経変性疾患 |
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| Outline of Final Research Achievements |
We examined the brains of GGT-type III, using an anti-tau oligomer-specific polyclonal antibody, T22 and anti-phosphorylated tau antibody, AT8. Predominant occurrence of GAIs was also confirmed with AT8 and T22. We consider that GGT are different from other 4R tauopathies not only in their pathological picture but also in their constituent tau species. It is tempting to speculate that GAIs represent a distinct, 4R tau-oligomer astrocytopathy that characterizes GGT.
We also performed a pathological and clinical investigation in 40 consecutive autopsied patients with pathological diagnoses of PSP-related disease. Unequivocal TAs were present in 22 cases, all of which were confirmed to be PSP. Such TAs were hardly observed in the other 18 cases. Cluster analysis of the distribution pattern of tau-related pathology for these 18 cases identified two subgroups, pallido-nigro-luysian atrophy (PNLA) Type 1 (n = 9) and Type 2 (n = 9).
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| Free Research Field |
神経病理学
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