Effects of overdose of fructose on dementia

2016 Fiscal Year Final Research Report

• Project/Area Number: 26430055
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Nerve anatomy/Neuropathology
• Research Institution: Kagawa University
• Principal Investigator: UENO Masaki 香川大学, 医学部, 教授 (30322267)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 果糖 / 脈絡叢 / グルコース輸送体 / 認知症

Outline of Final Research Achievements

Immunoreactivity of GLUT5 and GLUT8 was located in epithelial cells of the choroid plexus and ependymal cells. Immunoreactivity of GLUT8 was located in the cytoplasm of astrocytes and microglia. It is likely that intravascular substance including sugars was transported to periventricular areas. These findings suggest that intravascular fructose migrates to periventricular areas. Culture experiments under high concentration of fructose for short and long periods were conducted by evaluating not only survival rates, production of reactive oxygen species (ROS), and effects on the outgrowth of cultured neurons, but also survival rates and ROS production of cultured microglia. Although the survival rate of cultured neurons for a long period had decreased slightly, other parameters were significantly changed.

Free Research Field

神経病理学