Regulation of brian amyloid deposition by angiotensin receptor type Ia

2016 Fiscal Year Final Research Report

• Project/Area Number: 26430057
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Nerve anatomy/Neuropathology
• Research Institution: Iwate Medical University
• Principal Investigator: ZOU KUN 岩手医科大学, 薬学部, 講師 (40450837)
• Co-Investigator(Renkei-kenkyūsha): KOMANO HIROTO 岩手医科大学, 薬学部, 教授 (40170378)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: アルツハイマー病 / 高血圧症 / アンギオテンシン受容体

Outline of Final Research Achievements

Alzheimer's disease (AD)is characterized by neuronal loss and cerebral accumulation of amyloid-β protein (Aβ) and lowering the generation of Aβ is a pivotal approach in the strategy of Alzheimer's disease treatment. Midlife hypertension is a major risk factor for the future onset of sporadic AD and the use of some antihypertensive drugs may decrease the incidence of AD. However, it is largely unknown how the blood pressure regulation system is associated with the pathogenesis of AD. Here we found that the deficiency of angiotensin type 1a receptor (AT1a), a key receptor for regulating blood pressure, significantly decreased Aβ generation and amyloid plaque formation in a mouse model of AD. Our results suggest that removal of life style factors or stresses that stimulate AT1a to elevate blood pressure may decrease Aβ generation and brain amyloid accumulation, thereby preventing the pathogenesis of AD.

Free Research Field

神経科学、生化学