2016 Fiscal Year Final Research Report
Simultaneous control of the production and degradation of Amyloid be-ta by Sphingosine kinase/sphingosine-1-phosphate signaling
Project/Area Number |
26430059
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Nerve anatomy/Neuropathology
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Research Institution | Okayama University (2015-2016) Juntendo University (2014) |
Principal Investigator |
|
Co-Investigator(Renkei-kenkyūsha) |
TOMITA Taisuke 東京大学, 大学院 薬学系研究科, 教授 (30292957)
|
Project Period (FY) |
2014-04-01 – 2017-03-31
|
Keywords | アルツハイマー病 / S1P / SphK2 / 脂質代謝酵素 |
Outline of Final Research Achievements |
Alzheimer disease (AD)is a progressive neurodegenerative disease. The over-production and aggregation of Amyloid beta (Aβ) peptides in brains are considered to be the major pathogenic event for AD. We identified Sphingosine kinase 2 (SphK2) activity is upregulated in AD, and caused to increase the level of Aβ. These results strongly suggest SphK2 and its product sphingosine-1-phosphate are the therapeutic target for AD.
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Free Research Field |
生物系薬学
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