Effect of experimental diabetes on the emotional disability and their biological mechanims.

2017 Fiscal Year Final Research Report

• Project/Area Number: 26430062
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Neurochemistry/Neuropharmacology
• Research Institution: Gunma University
• Principal Investigator: Miyata Shigeo 群馬大学, 大学院医学系研究科, 助教 (40366836)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Keywords: 糖尿病 / うつ病 / モデル動物 / 情動行動

Outline of Final Research Achievements

There are increasing evidence that patients with diabetic mellitus (DM) have a higher prevalence to major depressive disorder than the general population; however, the biological mechanisms are still unclear. Here, we examined the effect of experimental DM on the emotional function and the metabolites profile in the brain in mice. DM mice exhibited the higher levels of blood glucose and the lower body weights. DM mice showed the abnormal behaviors. The brain metabolite levels were also altered in DM mice. The treatment with insulin dose-dependently and significantly improved these abnormalities. We found that the trophic factor receptor-mediated signaling was a candidate associated with the emotional disability in DM mice. Overall, we suggest the possibility that DM affects the emotional function mediated, at least in part, by disrupting the regulation the metabolites-associated signaling.

Free Research Field

神経科学、精神薬理学