2016 Fiscal Year Final Research Report
Screening of molecules responsible for signaling from nucleus to synapses in emotional memory
| Project/Area Number |
26430076
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurochemistry/Neuropharmacology
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| Research Institution | Toyo University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | シナプス可塑性 / 遺伝子発現 / PC12細胞 / 突起伸長 / 樹状突起スパイン |
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| Outline of Final Research Achievements |
It is well known that CRE transcriptional regulation and structural change in synapses are essential for emotional memory formation. However, the molecular basis is not clear. ICER, which is a CRE transcription repressor, suppresses emotional memory formation in mice. The aim of the study is to identify the ICER target genes and to investigate the involvement of ICER in synaptic structural changes. Using gene expression system, we revealed that ICER promotes the elongation of protrusion in neuronal model cells and the change in dendritic spines of primary cultured neurons. In addition, we were able to identify ICER target gene candidates in ICER-over expressing PC 12 cells. The results of this study are expected to contribute not only to the molecular mechanism of memory formation but also to elucidation of the cause of psychiatric disorders such as dementia and PTSD.
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| Free Research Field |
分子神経生物学
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