Role of microglia on brain development through maternal IgG-Fcgamma receptor pathway.

2017 Fiscal Year Final Research Report

• Project/Area Number: 26430081
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Neurochemistry/Neuropharmacology
• Research Institution: The University of Tokyo (2015-2017); The Institute of Physical and Chemical Research (2014)
• Principal Investigator: OUCHIDA Rika 東京大学, 医科学研究所, 助教 (80391887)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Keywords: ミクログリア / IgG抗体 / Fcγ受容体 / 貪食

Outline of Final Research Achievements

This research has been aimed to analyze the physiological role of microglia in the developing brain through the maternal IgG and its receptor Fcγ receptor expressed on microglia. As a result, the maternally derived IgG actually flowed into the fetal brain, and also the Fcγ receptors were highly expressed on the surface of microglial especially in the early stage of development. Through the IgG and Fcγ receptor pathway, a large amount of dead cells which are generated during brain development were taken up by the fetal microglia. These results suggested that the fetal microglia might regulate the brain construction physiologically by their phagocytosis function through IgG-Fcγ receptor pathway.

Free Research Field

脳内免疫学