Lysophosphatidic acid induces anxiety-like behavior via its receptors in mice

2016 Fiscal Year Final Research Report

• Project/Area Number: 26430082
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Neurochemistry/Neuropharmacology
• Research Institution: National Center of Neurology and Psychiatry
• Principal Investigator: Yamada Mitsuhiko 国立研究開発法人国立精神・神経医療研究センター, 精神保健研究所 精神薬理研究部, 部長 (60240040)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 抗うつ薬 / 情動行動

Outline of Final Research Achievements

We previously reported that altered expression of the LPA-related genes in rodents after treatment with a selective serotonin reuptake inhibitor, sertraline, which is widely used to treat depression. However, little is known about the behavioral effects of LPA. In the present study, we investigated the effects of LPA on emotional behaviors in adult mice. Intracerebroventricular injection of LPA induced behavioral changes in mice hole-board test, elevated plus maze test and forced swim test, through LPA receptors. Interestingly, administration of a LPA receptor antagonist BrP-LPA into the ventral hippocampus produced anxiolytic-like effect in mice. In vivo microdialysis experiments revealed that local perfusion of BrP-LPA in the ventral hippocampus induced increase in extracellular glutamate and GABA levels. In conclusion, LPA signaling plays important roles in emotional behaviors in mice.

Free Research Field

精神神経薬理学