2016 Fiscal Year Final Research Report
Exploration of genes responsible to abnormal behavior of adult mouse caused by malnutrition in fetal life
| Project/Area Number |
26430098
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Laboratory animal science
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| Research Institution | Institute of Physical and Chemical Research |
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Principal Investigator |
Furuse Tamio 国立研究開発法人理化学研究所, バイオリソースセンター, 開発研究員 (60392106)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 胎児期栄養 / マウス / 行動 / エピジェネティクス / 発達障害 |
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| Outline of Final Research Achievements |
Progenies that had been exposed to in utero protein restriction exhibited alteration of behavioral phenotypes, gene expression patterns, and genomic methylation patterns in the brain. We generated knockout (KO) mouse differentially expressed or methylated in the brain of the progenies of protein restricted group that are thought to be involved in developmental disorders. Behavioral phenotypes of the KO mice were analyzed comprehensively. In the analyses, the KO mice exhibited altered behavioral phenotypes relative to wild type such as deficit fear and short term memories, decrease of pre-pulse inhibition, suppressed social interaction.
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| Free Research Field |
実験動物遺伝学
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