2016 Fiscal Year Final Research Report
The role of DEK oncogene in normal and cancer stem cells
| Project/Area Number |
26430111
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Tumor biology
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| Research Institution | Gifu University |
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Principal Investigator |
Hara Akira 岐阜大学, 大学院医学系研究科, 教授 (10242728)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Keywords | 腫瘍 / 再生 |
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| Outline of Final Research Achievements |
We have generated doxycyclin-inducible Dek transgenic mouse. Dek induction unchanged the histology of the mouse tissues in the normal condition. However, when exposed to the carcinogen, the DEk-inducible mouse enhanced the tumor proliferation and tumor progression in the organ with squamous cell epithelium. Dek overexpression enhanced the G1/S transition in tumor cells. We have clarified Dek is the true oncogene. The target therapy against the DEK in cancers will be promised in the future.
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| Free Research Field |
再生医学
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