2016 Fiscal Year Final Research Report
Molecular research of non-histone lysine methylation in cancer epigenome and its potential as a therapeutic target
| Project/Area Number |
26430116
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Tumor biology
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| Research Institution | Osaka University (2015-2016)
Kyushu University (2014) |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | DNA損傷修復応答 / クロマチン / がん |
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| Outline of Final Research Achievements |
A variety of epigenetic changes occur early in carcinogenesis in parallel with genetic mutations and represent in cancer development. The cancer epigenome is regulated by many kinds of factors, such as DNA methylation, chromatin factors and their posttranslational modification, while these precise molecular mechanisms are largely unknown.
In this research, I focused on lysine methylation, which is important for chromatin dynamics in DNA damage response, and analyzed their biological function aiming to control the cellular sensitivity against anti-cancer reagents. I have identified lysine methyltransferases that are required for proper recruitment of repair factors on damaged chromatin and clarified their molecular mechanisms. These molecules potentially present new opportunities for deriving therapeutic strategies for cancer.
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| Free Research Field |
腫瘍分子生物学
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