Biological function of aryl hydrocarbon receptor in colon cancer

2016 Fiscal Year Final Research Report

• Project/Area Number: 26430131
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Tumor biology
• Research Institution: Research Institute for Clinical Oncology, Saitama Cancer Center
• Principal Investigator: Ikuta Togo 埼玉県立がんセンター(臨床腫瘍研究所), 臨床腫瘍研究所, 研究員 (00262072)
• Co-Investigator(Renkei-kenkyūsha): KOIKE Aki 量子科学技術研究開発機構, 放射線医学総合研究所 加速器工学部 治療ビーム研究開発チーム, 技術員 (50415410)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 大腸がん / がん予防 / AhR / 炎症 / ケモカイン

Outline of Final Research Achievements

We investigated tumor suppressive effect of indole-3-carbinol (I3C), which is the bioactive component contained in cruciferous vegetables, by studying the mice fed with the diet containing I3C or by examining culture cells treated with I3C. The former resulted in suppression of innate immunity-related genes in the intestine, the latter showed growth inhibitory effect. In addition, it was shown that inflammatory cytokine promoted cell proliferation in the primary culture system of intestinal epithelia. These results suggest that I3C suppresses cell proliferation by regulating inflammatory responses through its receptor.

Free Research Field

分子細胞生物学