Analyses of epigenomic variation such as DNA methylation due to obesity conditions by high nutrient intake.

2016 Fiscal Year Final Research Report

• Project/Area Number: 26430139
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Tumor biology
• Research Institution: National Cancer Center Japan
• Principal Investigator: FUJII GEN 国立研究開発法人国立がん研究センター, 研究所, 主任研究員 (90321877)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 遺伝子環境交互作用 / 肥満 / DNAメチル化

Outline of Final Research Achievements

Cancer is a disease of genes, and also is a disease strongly influenced from the environment. In recent years, obesity has formed an environment called mild chronic inflammation, and the mechanism by which cancer develops from it has drawn attention.
Therefore, in this study, we verified high nutrient intake in cultured cells or in mice brought into obesity conditions can evoke epigenomic changes such as DNA methylation occur at such frequencies as to explain the carcinogenic processes.
As a result, it was revealed that the DNA methylation state could be changed depending on the nutrient condition by long-term cultivation in the sugar-rich medium / lipid-rich medium in the experiment on the cultured cell level. We continue to conduct similar experiments and measurements also at the animal individual level.

Free Research Field

発がん予防