Genomic instability of ALK fusion positive lung adenocarcinoma

2017 Fiscal Year Final Research Report

• Project/Area Number: 26430149
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Tumor diagnostics
• Research Institution: Japanese Foundation for Cancer Research
• Principal Investigator: NINOMIYA HIRONORI 公益財団法人がん研究会, がん研究所 病理部, 研究員 (20462228)
• Co-Investigator(Kenkyū-buntansha): 石川 雄一 公益財団法人がん研究会, がん研究所 病理部, 部長 (80222975)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Keywords: 肺腺癌 / ALK融合遺伝子 / ゲノム不安定性 / クロモトリプシス

Outline of Final Research Achievements

We analyzed surgically resected pulmonary adenocarcinomas with Copy number analyzer for GeneChip (CNAG). The result revealed that frequent copy number change occurred on the short arm of chromosome 2 among ALK fusion positive cases. Same genomic alteration patter was detected in 10 cases among 35 (28.5%). On the other hand, no case showed similar copy number change among ALK fusion negative cases. The result revealed that genomic fragmentation and reconstruction is a notable mechanism of ALK fusion gene formation leading to carcinogenesis.

Free Research Field

呼吸器病理