2016 Fiscal Year Final Research Report
Development of a new molecular targeted therapy focused on lipid rafts for renal cell carcinoma
| Project/Area Number |
26430153
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Tumor therapeutics
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Research Collaborator |
ITOH Jun 東北大学, 医学系研究科, 大学院生
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | DSGb5 / 腎癌 / 糖脂質 / 糖鎖 |
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| Outline of Final Research Achievements |
We have focused on the role of glycolipid on renal cancer cells in terms of their ability of proliferation and motility. And in our past study, we have identified new glycolipid DSGb5 which was associated to cancer metastasis. Our past data also showed that DSGb5 was one of elements of lipid rafts (like floating) on lipid bilayer membrane of renal cancer cells. However, it was not known that lipid rafts including DSGb5 could be the therapeutic target of renal cancer. In this study we demonstrated that the high expression of DSGb5 promoted proliferation of renal cancer cells. Moreover, we elucidated that the high expression of DSGb5 was associated to vessel invasion of renal cancer caused to poor prognosis by investigating clinical specimens. According to our results lipid rafts including DSGb5 could be the therapeutic target with new mechanism employing glycobiological approach for advanced renal cancer.
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| Free Research Field |
泌尿器生殖器癌
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