2016 Fiscal Year Final Research Report
Regulation of Topisomerase I activity by cMet in lung cancer
| Project/Area Number |
26430159
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Tumor therapeutics
|
|---|
| Research Institution | Kanazawa University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Keywords | cMet / Topoisomerase I / Lung cancer |
|---|
| Outline of Final Research Achievements |
We examined the relationship between cMet and Topoisomerase I lung cancer. Protein expression and phosphorylation of cMet using 10 lung cancer cell lines revealed high expression and hyperphosphorylation in 5 cell line.Expression and activity of Topo I were higher in cMet overexpressing cells and were related to the sensitivity of Topo I inhibitors. Inhibition of cMet by Met inhibitor also decreased Topo I. Upon examination of the downstream signaling, 29 candidate genes associated with Topo I expression were identified by cMet stimulation and suppression. In analysis using clinical donation, cMet nominated positive with 37.7% and TopoI at 51.3%, showing a significant correlation. This study suggests that cMet may regulate the expression of Topo I and we believe that it will bring important findings to establish future treatment strategies
|
| Free Research Field |
呼吸器内科 胸部悪性腫瘍の治療
|
